Three Post-doctoral positions in natural product chemistry

1- Understanding and mimicking natural product complexity

 Offer description: post-doctoral fellowship (15 to 18 months) starting early 2023.

 Location: BioCIS, Université Paris-Saclay, Orsay, France.

 Project: it will associate bio-inspired total synthesis of complex natural products, quantum mechanics-based biosynthetic pathway evaluation and anticipation of molecular complexity with integrated workflows of hyphenated analytical and chemoinformatics tools (in close collaboration with the following offer).1

 Required skills:, organic synthesis, LC-MS, NMR, DFT calculations, experience in (or high motivation to learn) chemoinformatics (especially from mass spectrometry data), independence and initiative.

 Contacts: Prof. Mehdi Beniddir (mehdi.beniddir@universite-paris-saclay.fr), Prof. Erwan Poupon (erwan.poupon@universite-paris-saclay.fr).

2- Anticipating natural product complexity : in silico metabolic network

 Offer description : post-doctoral fellowship (15 months) starting early 2023

 Location : UMR8038 CiTCoM, Université Paris Cité, Paris, France

 Project : In its current state, MetWork2 relies on expert knowledge for the modification of metabolites and it is the responsibility of the user to define and select the chemical transformations. The post-doctoral researcher will improve the current methodology by using biochemical reactions and metabolic pathways knowledge to define the transformations used by MetWork to propose new metabolites. (in close collaboration with the first offer).

 Required skills : Python programming, bioinformatics, cheminformatics

 Contacts : Dr Grégory Genta-Jouve (gregory.genta-jouve@cnrs.fr)

3 – Formalizing “underground metabolism” to understand and exploit the evolutionary emergence of molecular complexity of natural substances

– Job description: post-doctoral fellowship (12 months) starting mid 2023

– Location: BioCIS, Université Paris-Saclay, Orsay, France

– Project: evaluating/formalizing the power of « underground metabolism » to let molecular complexity emerge in the field of natural product biosynthesis. Especially through enzymic promiscuity and spontaneous cascade reactions. Applications to the total synthesis of polycyclic natural products.

– Required skills: Organic synthesis, natural product chemistry, desired experience in biocatalysis, NMR, experience in (or high motivation to learn) chemoinformatics (especially from mass spectrometry data) and high-throughput experimentation.

– Contacts: Prof. Erwan Poupon (erwan.poupon@universite-paris-saclay.fr) and Prof. Mehdi Beniddir (mehdi.beniddir@universite-paris-saclay.fr)

– Application: via https://emploi.cnrs.fr/, cover letter and CV with contact details for at least two letters of reference. Deadline: April 12^th 2023.

Postdoc position in China: chemical ecology of seeds and seedlings (Xishuangbanna Tropical Botanical Garden, CAS)

General information

Workplace : Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Yunnan Province, CHINA. The garden’s website (http://english.xtbg.cas.cn) provides a very complete overview of the facilities and the research and other activities carried out at XTBG.
Name of the responsible scientists : Doyle McKey (CEFE, Montpellier, and visiting professor at XTBG) and Jin Chen (Professor, director of XTBG)
Type of contract : CDD
Contract period : two years, can be prolonged
Start date : Ideally March 2020, can be discussed
Proportion of work : Full time
Remuneration : 15 000 RMB (Yuan) monthly (= 1937 € or $US 2180), coupled with very low living expenses (see details below)
Eligibility : Applicants should be younger than 35 years old, and should have obtained the PhD degree within the last three years.

Detail description of the project:

Post-doc Position description_XTBG_Chemical_ecology_seeds_and_seedlings

CIFRE-type PhD offer at ICSN on marine natural product chemistry

Identification of compounds from the mother-of-pearl, their activity on bones and the synthesis of analogues

Internship to produce terpenes in microbial chassis with automation

The project IRIS FRAGRANCE incubated in the SHAKER program at the Genopole and support by the SATT Lutech aims to build a microbial chassis for industrial production of prized flavors and fragrances from the family of ionone molecules. Some of these molecules are sold as mixtures of racemic isomers. It is known that two enantiomers can have completely different scents, therefore a mixture is of compromised quality. Synthetic biology allows to produce enantiopure molecules.

PhD Position available on non-ribosomal peptide chemistry at Perpignan

A PhD position is available at the University of Perpignan on the synthesis and biotransformation non-ribosomal peptides. Contact for more information: Bernard Banaigs.

Link to the offer

PhD position in natural product chemistry and yeast metabolomic

A PhD position is available at the University of Rouen on the identification and mapping of yeast secondary metabolites. Contact for more information: Isabelle Schmitz-Afonso.

Link to the offer

Postdoc offer in analytical chemistry applied to oenology (Bordeaux, France)

Characterization of taste-active compounds responsible for sweetness of dry wines

Applications are invited for a 2-years post-doctoral fellowship in analytical chemistry applied to enology in the Institute of Vine and Wine Sciences of the University of Bordeaux. The successful candidate will be involved in the research of taste-active compounds responsible for sweetness of dry wines. So, the candidate will be involved in the characterization and isolation of natural products. A non-targeted approach will also be implemented by metabolomics studies using LC-HRMS.

Job offer in metabolomic MS

URGENT CDD 12 mois – Assistant ingénieur en techniques d’analyse de biomolécules

What: job offer for an Engineer in biomolecule analysis
Where: Roscoff Biological Station (Brittany, France)
When: as soon as possible
Deadline: 20/10/2016

Find the complete job offer (in French) here.

Contact: Catherine Leblanc and Cedric Leroux

PhD position at the National Museum of Natural History

We are looking for a student with a Master degree in chemical ecology or natural product chemistry to work on this project on the History of an evolutionary convergence: evolution of chemical defenses within mimetic butterflies communities. The student will have to perform chemical analyses on biological material using various innovative analytical techniques. Together with those lab skills, the student should display a high motivation for fieldwork in tropical areas. The PhD thesis will start in October 2016. Application files should contain: a CV, a cover letter, Master score sheets, and two recommendation letters. Complete application files must be sent to Dr. Violaine Llaurens and Dr. Bastien Nay before March 30th. Selected candidates will then be interviewed by a selection committee in May. The PhD will start on October 1st, 2016.

Link to the PhD project and conditions