CNRS joint unit “Molécule de Communication et Adaptation des Micro-organismes” (UMR 7245 CNRS-MNHN)
Contacts: Prof. Soizic Prado/Dr. Yanyan Li
Mails: soizic.prado@mnhn.fr/yanyan.li@mnhn.fr
Phones: + 33 1 40 79 31 19/+ 33 1 40 79 57 91
The French National Museum of Natural History (MNHN) was created in 1635 as the Royal Garden of medicinal plants and took its Museum attribute after the French Revolution in 1793. Today, at the crossroads of the Earth, life and human sciences, the Museum’s five missions – conservation, research, higher education, expertise and public awareness – are broad in scope and interdisciplinary.
The MNHN-CNRS joint unit “Molecules of communication and adaptation of micro-organisms” (joint unit number UMR 7245) welcomes four teams working on the natural chemical factors (secondary metabolites, peptides, proteins) and the mechanisms that govern interactions between micro-organisms, their environment or their host. A major interest concerns the molecular mechanisms involved in communication, defense, parasitism, symbiosis and mutualism associations, with various research models involving bacteria, cyanobacteria, fungi and protozoa. This unit hosts research facilities like two NMR (400 and 600 MHz with cryoprobe), one LC-HRMS spectrometer (especially ESI-QTOF-MS/MS), various fermentation and biological screening services, and several microbial collections and a chemical library. Moreover, the unit provides access to instruments for RT-PCR, bio-essay (e.g. nephelometer), FACS etc.
In this context, natural product chemistry teams aims at studying the organic and bio-organic bases of microbial interactions in the natural context, using isolation, synthetic and biosynthetic studies, from genes to molecules, and from compounds to their biological roles and applications.
an IRN on Integrative Natural Product Chemistry 