University of Warwick

Laboratory of Molecular assembly lines and combinatorial biosynthesis

Principal contact: Dr. Christophe Corre
Mail: c.corre@warwick.ac.uk
Phone: + 44 2476 523 557

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Our group has three main research themes:

  1. Bacterial Transcriptional Regulators: We investigate the molecular mechanisms by which bacteria control the biosynthesis of natural products. Different families of transcription factors regulate the expression of gene clusters that direct the assembly of these natural products.

  2. Bioactive Natural Products: We investigate the molecular mechanisms by which bacteria control the biosynthesis of natural products. Different families of transcription factors regulate the expression of gene clusters that direct the assembly of these natural products.

    Our detailed understanding of such regulatory systems opens the way to the discovery of new moleculesfrom metabolic pathways which are typically silent in the laboratory environment. Indeed, we have been able to rationally inactivate specific transcriptional repressor genes and/or overexpress transcriptional activators to discover novel bioactive metabolites (i.e. antibiotics, anticancer)

     

  3. Biocatalysts: The structural diversity of microbial natural products also relies on the activity of specialized/unique sets of enzymes able to assemble these complex structures. These proteins can be developed and exploited as biocatalysts for the manufacture of high value chemicals.