Cytotoxic Prenylated Stilbenes from Macaranga tanarius, from GDRI members partnership

Recent paper from a GDRI members partnership in WP2:

Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius
Tiphaine Péresse, Gwenaëlle Jézéquel, Pierre-Marie Allard, Van-Cuong Pham, Doan T. M. Huong, Florent Blanchard, Jérôme Bignon, Hélène Lévaique, Jean-Luc Wolfender, Marc Litaudon, and Fanny RoussiJournal of Natural Products 2017, DOI: 10.1021/acs.jnatprod.7b00409

jnp2017_Roussi

Abstract: With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K–Q (713), were isolated, along with vedelianin (1), schwenfurthins E–G (24), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 113 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.

 

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